Ecstasy and neurodegeneration

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Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’): Neurodegeneration versus Neuromodulation

The amphetamine analogue 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) is widely abused as a recreational drug due to its unique psychological effects. Of interest, MDMA causes long-lasting deficits in neurochemical and histological markers of the serotonergic neurons in the brain of different animal species. Such deficits include the decline in the activity of tryptophan hydroxylase in p...

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Ecstasy is a recreational drug that is increasing in popularity, particularly in young adolescents. Its appeal involves its euphoric effects and a feeling of empathy for others (hence the nickname "hug drug"). This appeal may be furthered by a misleading and anecdotal perception of safety. Cases of adverse effects, toxic reactions, and fatalities are increasingly being reported in the medical l...

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Ecstasy: pharmacology and neurotoxicity.

In part because it is amphetamine derived, ecstasy has inherited some of its parent compound's reputation for being neurotoxic. However, whereas amphetamine and methamphetamine undoubtedly cause irreversible brain damage with long-term use, the jury is still out on the party drug ecstasy. The deadly reputation of ecstasy has been fuelled by the tragic fates of healthy young clubbers who have di...

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ژورنال

عنوان ژورنال: BMJ

سال: 1996

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.313.7054.423